論文

2025

• Dai S, Peng H, Kato Y, Arakawa H. Role of organic anion transporter 2 in the efflux of raltegravir glucuronide from the endoplasmic reticulum in the liver. Biochem Pharmacol. 2025 Aug 13;242(Pt 1):117230. doi: 10.1016/j.bcp.2025.117230
• Peng H, Takahashi E, Murakami T, Saito Y, Kamezaki K, Watanabe A, Kusuhara H, Nakagawa-Goto K, Jimbo Y, Arakawa H. Evaluation of Puberulic Acid-Induced Nephrotoxicity Using 3D-RPTEC. Biol Pharm Bull. 2025;48(6):928-931. doi: 10.1248/bpb.b24-00654.
• Wang H, Meschini C, Poulain S, Kim SH, Arakawa H, Kato Y, Legallais C, Pereira U, Sakai Y, Leclerc E. 3D hepatic spheroids and liver-organ on chip models displayed maintenance of hepatic functions and maturation profile in a long-term culture of the humanized HepaSH cells, a human cell population harvested from chimeric mice. Biotechnol Prog. 2025 May 31:e70043. doi: 10.1002/btpr.70043.
• Jing Y, Kobayashi M, Shoulkamy MI, Zhou M, Thi Vu H, Arakawa H, Sabit H, Iwabuchi S, Quang Vu C, Kasahara A, Ueno M, Tadokoro Y, Kurayoshi K, Chen X, Yan Y, Arai S, Hashimoto S, Soga T, Todo T, Nakada M, Hirao A. Lysine-arginine imbalance overcomes therapeutic tolerance governed by the transcription factor E3-lysosome axis in glioblastoma. Nat Commun. 2025 Apr 1;16(1):2876. doi: 10.1038/s41467-025-56946-z
• Wang H, Danoy M, Gong Y, Utami T, Arakawa H, Kato Y, Nishikawa M, Sakai Y, Leclerc E. Palmitic Acid Induced a Dedifferentiation Profile at the Transcriptome Level: A Collagen Synthesis but no Triglyceride Accumulation in Hepatocyte-Like Cells Derived From Human-Induced Pluripotent Stem Cells Cultivated Inside Organ on a Chip. J Appl Toxicol. 2025 Mar;45(3):460-471. doi: 10.1002/jat.4714.
• Arakawa H, Takayama K. Future direction of animal alternative/microphysiological systems in drug discovery and development. Drug Metab Pharmacokinet. 2025 Apr;61:101479. doi: 10.1016/j.dmpk.2025.101479.

2024

• Wen S, Arakawa H, Yokoyama S, Shirasaka Y, Higashida H, Tamai I. Functional identification of soluble uric acid as an endogenous inhibitor of CD38. Elife. 2024 Nov 11;13:RP96962. doi: 10.7554/eLife.96962.
• Ueno M, Sugiyama H, Li F, Nishimura T, Arakawa H, Chen X, Cheng X, Takeuchi S, Takeshita Y, Takamura T, Miyagi S, Toyama T, Soga T, Masuo Y, Kato Y, Nakamura H, Tsujiguchi H, Hara A, Tajima A, Noguchi-Shinohara M, Ono K, Kurayoshi K, Kobayashi M, Tadokoro Y, Kasahara A, Shoulkamy MI, Maeda K, Ogoshi T, Hirao A. A Supramolecular Biosensor for Rapid and High-Throughput Quantification of a Disease-Associated Niacin Metabolite. Anal Chem. 2024 Sep 10;96(36):14499-14507. doi: 10.1021/acs.analchem.4c02653.
• Arakawa H, Higuchi D, Takahashi E, Matsushita K, Nedachi S, Peng H, Kadoguchi M, Morimura K, Araki A, Kondo M, Ishiguro N, Jimbo Y, Tamai I. Three-dimensional culture of human proximal tubular epithelial cells for an in vitro evaluation of drug-induced kidney injury. J Pharm Sci. 2024 Nov;113(11):3255-3264. doi: 10.1016/j.xphs.2024.08.009.
• Ishida N, Katsura A, Takagaki K, Arakawa H, Shimada T, Mizuno S, Sai Y, Kato Y, Nakamura H, Suga Y, Matsushita R. Transdermal pilocarpine on the skin over salivary glands to increase salivation: an in vivo study. BMC Oral Health. 2024 Aug 2;24(1):881. doi: 10.1186/s12903-024-04667-y.
• Hashiba S, Nakano M, Yokoseki I, Takahashi E, Kondo M, Jimbo Y, Ishiguro N, Arakawa H, Fukami T, Nakajima M. Cytochrome P450 and UDP-Glucuronosyltransferase Expressions, Activities, and Induction Abilities in 3D-Cultured Human Renal Proximal Tubule Epithelial Cells. Drug Metab Dispos. 2024 Aug 14;52(9):949-956. doi: 10.1124/dmd.124.001685.
• Arakawa H, Ishida N, Nakatsuji T, Matsumoto N, Imamura R, Shengyu D, Araya K, Horike SI, Tanaka-Yachi R, Kasahara M, Yoshioka T, Sumida Y, Ohmiya H, Daikoku T, Wakayama T, Nakamura K, Fujita KI, Kato Y. Endoplasmic reticulum transporter OAT2 regulates drug metabolism and interaction. Biochem Pharmacol. 2024 Jul;225:116322. doi: 10.1016/j.bcp.2024.116322.
• Miyajima Y, Karashima S, Mizoguchi R, Kawakami M, Ogura K, Ogai K, Koshida A, Ikagawa Y, Ami Y, Zhu Q, Tsujiguchi H, Hara A, Kurihara S, Arakawa H, Nakamura H, Tamai I, Nambo H, Okamoto S. Prediction and causal inference of hyperuricemia using gut microbiota. Sci Rep. 2024 Apr 30;14(1):9901. doi: 10.1038/s41598-024-60427-6.
• Fujita K, Isozumi N, Zhu Q, Matsubayashi M, Taniguchi T, Arakawa H, Shirasaka Y, Mori E, Tamai I. Unique Binding Sites of Uricosuric Agent Dotinurad for Selective Inhibition of Renal Uric Acid Reabsorptive Transporter URAT1. J Pharmacol Exp Ther. 2024 Jun 21;390(1):99-107. doi: 10.1124/jpet.124.002096.
• Imamura R, Sugimoto M, Horike SI, Terakawa J, Fujita K, Tamai I, Daikoku T, Kato Y, Arakawa H. Role of Organic Anion Transporter NPT4 in Renal Handling of Uremic Toxin 3-indoxyl Sulfate. J Pharm Sci. 2024 Jul;113(7):1996-2000. doi: 10.1016/j.xphs.2024.04.014.
• Fujita H, Arai S, Arakawa H, Hamamoto K, Kato T, Arai T, Nitta N, Hotta K, Hosokawa N, Ohbayashi T, Takahashi C, Inokuma Y, Tamai I, Yano S, Kunishima M, Watanabe Y. Drug-drug conjugates of MEK and Akt inhibitors for RAS-mutant cancers. Bioorg Med Chem. 2024 Mar 15;102:117674. doi: 10.1016/j.bmc.2024.117674.
• Scheidecker B, Poulain S, Sugimoto M, Kido T, Kawanishi T, Miyajima A, Kim SH, Arakawa H, Kato Y, Nishikawa M, Danoy M, Sakai Y, Leclerc E. Dynamic, IPSC-derived hepatic tissue tri-culture system for the evaluation of liver physiology in vitro. Biofabrication. 2024 Mar 25;16(2). doi: 10.1088/1758-5090/ad30c5.
• Kurniawan DA, Leo S, Inamatsu M, Funaoka S, Aihara T, Aiko M, Rei I, Sakura T, Arakawa H, Kato Y, Matsugi T, Esashika K, Shiraki N, Kume S, Shinha K, Kimura H, Nishikawa M, Sakai Y. Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism. PNAS Nexus. 2024 Feb 9;3(2):pgae070. doi: 10.1093/pnasnexus/pgae070. 
• Hashimoto K, Arakawa H, Imamura R, Nishimura T, Kitajima S, Sato T, Makiyama K, Ogawa T, Yokota S. A novel alternative method for long-term evaluation of male reproductive toxicity and its recovery using a pre-pubertal mouse testis organ culture system. J Appl Toxicol. 2024 May;44(5):784-793. doi: 10.1002/jat.4584.
• Utami T, Danoy M, Khadim RR, Tokito F, Arakawa H, Kato Y, Kido T, Miyajima A, Nishikawa M, Sakai Y. A highly efficient cell culture method using oxygen-permeable PDMS-based honeycomb microwells produces functional liver organoids from human induced pluripotent stem cell-derived carboxypeptidase M liver progenitor cells. Biotechnol Bioeng. 2024 Apr;121(4):1178-1190. doi: 10.1002/bit.28640.
• Scheidecker B, Poulain S, Sugimoto M, Arakawa H, Kim SH, Kawanishi T, Kato Y, Danoy M, Nishikawa M, Sakai Y. Mechanobiological stimulation in organ-on-a-chip systems reduces hepatic drug metabolic capacity in favor of regenerative specialization. Biotechnol Bioeng. 2024 Apr;121(4):1435-1452. doi: 10.1002/bit.28653.

2023

• Ishida N, Oshima Y, Katsura A, Imamura R, Arakawa H, Shimada T, Mizuno S, Sai Y, Suga Y, Matsushita R. Application Site of Transdermal Scopolamine Influences Efficacy and Drug Concentration in Salivary Glands in Rats. Biol Pharm Bull. 2023;46(12):1805-1809. doi: 10.1248/bpb.b23-00561.
• Fujita K, Zhu Q, Arakawa H, Shirasaka Y, Tamai I. Potentiation of the
  Uricosuric Effect of Dotinurad by Trans-Inhibition of the Uric Acid Reabsorptive Transporter 1. Drug Metab Dispos. 2023 Nov;51(11):1527-1535. doi: 10.1124/dmd.123.001412.
• Arakawa H, Kawanishi T, Shengyu D, Nishiuchi T, Meguro-Horike M, Horike SI, Sugimoto M, Kato Y. Renal Pharmacokinetic Adaptation to Cholestasis Causes Increased Nephrotoxic Drug Accumulation by Mrp6 Downregulation in Mice. J Pharm Sci. 2023 Dec;112(12):3209-3215. doi: 10.1016/j.xphs.2023.08.008.
• Arakawa H, Nakazono Y, Matsuoka N, Hayashi M, Shirasaka Y, Hirao A, Tamai I. Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion. Commun Biol. 2023 Aug 22;6(1):866. doi: 10.1038/s42003-023-05216-z.
• Ishiguro N, Takahashi E, Arakawa H, Saito A, Kitagawa F, Kondo M, Morinaga G, Takatani M, Takahashi R, Kudo T, Mae SI, Kadoguchi M, Higuchi D, Nakazono Y, Tamai I, Osafune K, Jimbo Y. Improvement of Protein Expression Profile in Three-Dimensional Renal Proximal Tubular Epithelial Cell Spheroids Selected Based on OAT1 Gene Expression: A Potential In Vitro Tool for Evaluating Human Renal Proximal Tubular Toxicity and Drug Disposition. Drug Metab Dispos. 2023 Sep;51(9):1177-1187. doi: 10.1124/dmd.122.001171.
• Tao F, Hanada S, Matsushima K, Arakawa H, Ishida N, Kato Y, Okimura S, Watanabe T, Kojima N. Enhancement and maintenance of hepatic metabolic functions by controlling 3D aggregation of cryopreserved human iPS cell-derived hepatocyte-like cells. J Biosci Bioeng. 2023 Feb;135(2):134-142. doi: 10.1016/j.jbiosc.2022.10.006.

2022

• Kadoguchi M, Arakawa H, Honda R, Hotta K, Shirasaka Y, Deguchi Y, Tamai I.
  Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier
  Model hCMEC/D3 Cells by Targeted siRNA Screening. Pharm Res. 2022
  Jul;39(7):1549-1559. doi: 10.1007/s11095-022-03223-z.
• Arakawa H, Nagao Y, Nedachi S, Shirasaka Y, Tamai I. Evaluation of Platinum
  Anticancer Drug-Induced Kidney Injury in Primary Culture of Rat Kidney Tissue
  Slices by Using Gas-Permeable Plates. Biol Pharm Bull. 2022;45(3):316-322. doi:
  10.1248/bpb.b21-00875.
• Danoy M, Scheidecker B, Arakawa H, Esashika K, Ishida N, Ito H, Yanai H, Takahashi J, Nishikawa M, Kato Y, Sakai Y*. Cryopreserved human hepatocytes culture optimization on polymethylpentene oxygen permeable membranes for drug screening purposes. Fundam Toxicol Sci, 2022;9:135-144. doi: 10.2131/fts.9.135.

2021

• Wen S, Arakawa H, Tamai I. CD38 activation by monosodium urate crystals
  contributes to inflammatory responses in human and murine macrophages. Biochem Biophys Res Commun. 2021 Dec 3;581:6-11. doi: 10.1016/j.bbrc.2021.10.010.
• Shinha K, Nihei W, Nakamura H, Goto T, Kawanishi T, Ishida N, Yamazaki N,
  Imakura Y, Mima S, Inamura K, Arakawa H, Nishikawa M, Kato Y, Sakai Y, Kimura H.
  A Kinetic Pump Integrated Microfluidic Plate (KIM-Plate) with High Usability for
  Cell Culture-Based Multiorgan Microphysiological Systems. Micromachines (Basel). 2021 Aug 24;12(9):1007. doi: 10.3390/mi12091007.
• Danoy M, Tauran Y, Poulain S, Jellali R, Bruce J, Leduc M, Le Gall M, Koui Y,
  Arakawa H, Gilard F, Gakiere B, Kato Y, Plessy C, Kido T, Miyajima A, Sakai Y,
  Leclerc E. Investigation of the hepatic development in the coculture of hiPSCs-
  derived LSECs and HLCs in a fluidic microenvironment. APL Bioeng. 2021 May
  10;5(2):026104. doi: 10.1063/5.0041227.
• Nakazono Y, Arakawa H, Nishino M, Yamaki I, Oba T, Tomotoshi K, Kakinuma C,
  Ogihara T, Tamai I. Drug Transcellular Transport Assay Using a High Porosity
  Honeycomb Film. Biol Pharm Bull. 2021;44(5):635-641. doi: 10.1248/bpb.b20-00925.
• Shinohara M, Arakawa H, Oda Y, Shiraki N, Sugiura S, Nishiuchi T, Satoh T,
  Iino K, Leo S, Kato Y, Araya K, Kawanishi T, Nakatsuji T, Mitsuta M, Inamura K,
  Goto T, Shinha K, Nihei W, Komori K, Nishikawa M, Kume S, Kato Y, Kanamori T,
  Sakai Y, Kimura H. Coculture with hiPS-derived intestinal cells enhanced human
  hepatocyte functions in a pneumatic-pressure-driven two-organ microphysiological system. Sci Rep. 2021 Mar 8;11(1):5437. doi: 10.1038/s41598-021-84861-y.
• Danoy M, Tauran Y, Poulain S, Jellali R, Bruce J, Leduc M, Le Gall M, Gilard
  F, Kido T, Arakawa H, Araya K, Mori D, Kato Y, Kusuhara H, Plessy C, Miyajima A,
  Sakai Y, Leclerc E. Multi-omics analysis of hiPSCs-derived HLCs matured on-chip
  revealed patterns typical of liver regeneration. Biotechnol Bioeng. 2021
  Oct;118(10):3716-3732. doi: 10.1002/bit.27667.
• Hashizume H, Fukami T, Mishima K, Arakawa H, Mishiro K, Zhang Y, Nakano M,
  Nakajima M. Identification of an isoform catalyzing the CoA conjugation of
  nonsteroidal anti-inflammatory drugs and the evaluation of the expression levels of acyl-CoA synthetases in the human liver. Biochem Pharmacol. 2021
  Jan;183:114303. doi: 10.1016/j.bcp.2020.114303.

2020

• Ueno M, Tomita T, Arakawa H, Kakuta T, Yamagishi TA, Terakawa J, Daikoku T,
  Horike SI, Si S, Kurayoshi K, Ito C, Kasahara A, Tadokoro Y, Kobayashi M,
  Fukuwatari T, Tamai I, Hirao A, Ogoshi T. Pillar[6]arene acts as a biosensor for
  quantitative detection of a vitamin metabolite in crude biological samples.
  Commun Chem. 2020 Dec 7;3(1):183. doi: 10.1038/s42004-020-00430-w.
• Arakawa H, Amezawa N, Kawakatsu Y, Tamai I. Renal Reabsorptive Transport of
  Uric Acid Precursor Xanthine by URAT1 and GLUT9. Biol Pharm Bull.
  2020;43(11):1792-1798. doi: 10.1248/bpb.b20-00597.
• Morishita H, Okawa K, Ishii M, Mizoi K, Ito MA, Arakawa H, Yano K, Ogihara T.
  Gastrointestinal absorption of pimozide is enhanced by inhibition of
  P-glycoprotein. PLoS One. 2020 Oct 29;15(10):e0232438. doi:
  10.1371/journal.pone.0232438.
• Yoshitani J, Kabata T, Arakawa H, Kato Y, Nojima T, Hayashi K, Tokoro M,
  Sugimoto N, Kajino Y, Inoue D, Ueoka K, Yamamuro Y, Tsuchiya H. Combinational
  therapy with antibiotics and antibiotic-loaded adipose-derived stem cells reduce
  abscess formation in implant-related infection in rats. Sci Rep. 2020 Jul
  7;10(1):11182. doi: 10.1038/s41598-020-68184-y.
• Arakawa H, Yamada H, Arai K, Kawanishi T, Nitta N, Shibata S, Matsumoto E,
  Yano K, Kato Y, Kumamoto T, Aoki I, Ogihara T. Possible utility of peptide-
  transporter-targeting [¹⁹F]dipeptides for visualization of the
  biodistribution of cancers by nuclear magnetic resonance imaging. Int J Pharm.
  2020 Aug 30;586:119575. doi: 10.1016/j.ijpharm.2020.119575.
• Danoy M, Tauran Y, Poulain S, Arakawa H, Mori D, Araya K, Kato S, Kido T,
  Kusuhara H, Kato Y, Miyajima A, Plessy C, Sakai Y, Leclerc E. Analysis of hiPSCs
  differentiation toward hepatocyte-like cells upon extended exposition to
  oncostatin. Differentiation. 2020 Jul-Aug;114:36-48. doi:
  10.1016/j.diff.2020.05.006.
• Ondo K, Arakawa H, Nakano M, Fukami T, Nakajima M. SLC35B1 significantly
  contributes to the uptake of UDPGA into the endoplasmic reticulum for
  glucuronidation catalyzed by UDP-glucuronosyltransferases. Biochem Pharmacol.
  2020 May;175:113916. doi: 10.1016/j.bcp.2020.113916.
• Arakawa H, Sugiura S, Kawanishi T, Shin K, Toyoda H, Satoh T, Sakai Y,
  Kanamori T, Kato Y. Kinetic analysis of sequential metabolism of triazolam and
  its extrapolation to humans using an entero-hepatic two-organ microphysiological system. Lab Chip. 2020 Feb 7;20(3):537-547. doi: 10.1039/c9lc00884e.
• Arakawa N, Nagao K, Murakami R, Sumida Y, Arakawa H, Inagaki F, Ohmiya H. Aliphatic Oxaboroles Enabling Remarkable Recognition of Diols. Bull Chem Soc Jpn, 2020;93:576-580. doi: 10.1246/bcsj.20200007.

2019

• Kawanishi T, Arakawa H, Masuo Y, Nakamichi N, Kato Y. Bile Duct Obstruction
  Leads to Increased Intestinal Expression of Breast Cancer Resistance Protein
  With Reduced Gastrointestinal Absorption of Imatinib. J Pharm Sci. 2019
  Sep;108(9):3130-3137. doi: 10.1016/j.xphs.2019.05.017.
• Arakawa H, Kubo H, Washio I, Staub AY, Nedachi S, Ishiguro N, Nakanishi T,
  Tamai I. Rat Kidney Slices for Evaluation of Apical Membrane Transporters in
  Proximal Tubular Cells. J Pharm Sci. 2019 Aug;108(8):2798-2804. doi:
  10.1016/j.xphs.2019.03.031.
• Kasahara F, Kato T, Idota Y, Takahashi H, Kakinuma C, Yano K, Arakawa H, Hara
  K, Miyajima C, Ogihara T. Reduction Effect of Calcium Alginate on Blood
  Triglyceride Levels Causing the Inhibition of Hepatic and Total Body
  Accumulation of Fat in Rats. Biol Pharm Bull. 2019;42(3):365-372. doi:
  10.1248/bpb.b18-00530.
• Arakawa H, Amezawa N, Katsuyama T, Nakanishi T, Tamai I. Uric acid analogue
  as a possible xenobiotic marker of uric acid transporter Urat1 in rats. Drug
  Metab Pharmacokinet. 2019 Apr;34(2):155-158. doi: 10.1016/j.dmpk.2018.12.003.

2018

• Omote S, Matsuoka N, Arakawa H, Nakanishi T, Tamai I. Effect of tyrosine
  kinase inhibitors on renal handling of creatinine by MATE1. Sci Rep. 2018 Jun
  18;8(1):9237. doi: 10.1038/s41598-018-27672-y.
• Koyama S, Arakawa H, Itoh M, Masuda N, Yano K, Kojima H, Ogihara T.
  Evaluation of the metabolic capability of primary human hepatocytes in three-
  dimensional cultures on microstructural plates. Biopharm Drug Dispos. 2018
  Apr;39(4):187-195. doi: 10.1002/bdd.2125.
• Ellawatty WEA, Masuo Y, Fujita KI, Yamazaki E, Ishida H, Arakawa H, Nakamichi
  N, Abdelwahed R, Sasaki Y, Kato Y. Organic Cation Transporter 1 Is Responsible
  for Hepatocellular Uptake of the Tyrosine Kinase Inhibitor Pazopanib. Drug Metab Dispos. 2018 Jan;46(1):33-40. doi: 10.1124/dmd.117.076554.

2017

• Arakawa H, Washio I, Matsuoka N, Kubo H, Staub AY, Nakamichi N, Ishiguro N,
  Kato Y, Nakanishi T, Tamai I. Usefulness of kidney slices for functional
  analysis of apical reabsorptive transporters. Sci Rep. 2017 Oct 9;7(1):12814.
  doi: 10.1038/s41598-017-12828-z.
• Ogihara T, Arakawa H, Jomura T, Idota Y, Koyama S, Yano K, Kojima H. Utility
  of human hepatocyte spheroids without feeder cells for evaluation of
  hepatotoxicity. J Toxicol Sci. 2017;42(4):499-507. doi: 10.2131/jts.42.499.
• Arakawa H, Kamioka H, Jomura T, Koyama S, Idota Y, Yano K, Kojima H, Ogihara
  T. Preliminary Evaluation of Three-Dimensional Primary Human Hepatocyte Culture System for Assay of Drug-Metabolizing Enzyme-Inducing Potential. Biol Pharm Bull. 2017;40(7):967-974. doi: 10.1248/bpb.b16-00885.
• Arakawa H, Omote S, Tamai I. Inhibitory Effect of Crizotinib on Creatinine
  Uptake by Renal Secretory Transporter OCT2. J Pharm Sci. 2017
  Sep;106(9):2899-2903. doi: 10.1016/j.xphs.2017.03.013.

2016

• Idota Y, Kogure Y, Kato T, Yano K, Arakawa H, Miyajima C, Kasahara F, Ogihara
  T. Relationship between Physical Parameters of Various Metal Ions and Binding
  Affinity for Alginate. Biol Pharm Bull. 2016;39(11):1893-1896. doi:
  10.1248/bpb.b16-00127.
• Yano K, Otsuka K, Kato Y, Kawabata H, Ohmori S, Arakawa H, Ogihara T.
  Different regulation of P-glycoprotein function between Caco-2 and Caki-1 cells
  by ezrin, radixin and moesin proteins. J Pharm Pharmacol. 2016 Mar;68(3):361-7.
  doi: 10.1111/jphp.12525.
• Arakawa H, Ohmachi T, Ichiba K, Kamioka H, Tomono T, Kanagawa M, Idota Y,
  Hatano Y, Yano K, Morimoto K, Ogihara T. Interaction of Peptide Transporter 1
  With D-Glucose and L-Glutamic Acid; Possible Involvement of Taste Receptors. J
  Pharm Sci. 2016 Jan;105(1):339-42. doi: 10.1016/j.xphs.2015.11.024.
• Kasai T, Nakanishi T, Ohno Y, Shimada H, Nakamura Y, Arakawa H, Tamai I. Role
  of OATP2A1 in PGE(2) secretion from human colorectal cancer cells via exocytosis in response to oxidative stress. Exp Cell Res. 2016 Feb 15;341(2):123-31. doi: 10.1016/j.yexcr.2016.02.002.
• Idota Y, Kogure Y, Kato T, Ogawa M, Kobayashi S, Kakinuma C, Yano K, Arakawa
  H, Miyajima C, Kasahara F, Ogihara T. Cholesterol-Lowering Effect of Calcium
  Alginate in Rats. Biol Pharm Bull. 2016;39(1):62-7. doi: 10.1248/bpb.b15-00503.
• Arakawa H, Kamioka H, Kanagawa M, Hatano Y, Idota Y, Yano K, Morimoto K,
  Ogihara T. Possible interaction of quinolone antibiotics with peptide
  transporter 1 in oral absorption of peptide-mimetic drugs. Biopharm Drug Dispos. 2016 Jan;37(1):39-45. doi: 10.1002/bdd.1999.

2015

• Tomono T, Otsuka K, Yano K, Kanagawa M, Arakawa H, Ogihara T. Recommended
  Daily Dose of Sesame Lignans Has No Influence on Oral Absorption of
  P-Glycoprotein Substrates in Rats. Biol Pharm Bull. 2015;38(12):1960-3. doi:
  10.1248/bpb.b15-00392.
• Yano K, Mita S, Morimoto K, Haraguchi T, Arakawa H, Yoshida M, Yamashita F,
  Uchida T, Ogihara T. Multiple Linear Regression Analysis Indicates Association
  of P-Glycoprotein Substrate or Inhibitor Character with Bitterness Intensity,
  Measured with a Sensor. J Pharm Sci. 2015 Sep;104(9):2789-94. doi:
  10.1002/jps.24232.
• Ogihara T, Iwai H, Inoue Y, Katagi J, Matsumoto N, Motoi-Ohtsuji M, Kakiki M, Kaneda S, Nagao T, Kusumoto K, Ozeki E, Jomura T, Tanaka S, Ueda T, Ohta T, Ohkura T, Arakawa H, Nagai D. Utility of human hepatocyte spheroids for evaluation of hepatotoxicity. Fundam. Toxicol Sci, 2015;2:41-48. doi: 10.2131/fts.2.41

2014

• Arakawa H, Saito S, Kanagawa M, Kamioka H, Yano K, Morimoto K, Ogihara T.
  Evaluation of a thiodipeptide, L-phenylalanyl-Ψ[CS-N]-L-alanine, as a novel
  probe for peptide transporter 1. Drug Metab Pharmacokinet. 2014;29(6):470-4.
  doi: 10.2133/dmpk.DMPK-14-RG-047.
• Ohkura T, Ohta K, Nagao T, Kusumoto K, Koeda A, Ueda T, Jomura T, Ikeya T,
  Ozeki E, Wada K, Naitoh K, Inoue Y, Takahashi N, Iwai H, Arakawa H, Ogihara T.
  Evaluation of human hepatocytes cultured by three-dimensional spheroid systems for drug metabolism. Drug Metab Pharmacokinet. 2014;29(5):373-8. doi:
  10.2133/dmpk.dmpk-13-rg-105.
• Zhang P, Idota Y, Yano K, Negishi M, Kawabata H, Arakawa H, Morimoto K, Tsuji
  A, Ogihara T. Characterization of cesium uptake mediated by a potassium
  transport system of bacteria in a soil conditioner. Biol Pharm Bull.
  2014;37(4):604-7. doi: 10.1248/bpb.b13-00871.

2012

• Arakawa H, Shirasaka Y, Haga M, Nakanishi T, Tamai I. Active intestinal
  absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion
  transporting polypeptide, Oatp1a5. Biopharm Drug Dispos. 2012 Sep;33(6):332-41.
  doi: 10.1002/bdd.1809.
• Arakawa H, Nakanishi T, Yanagihara C, Nishimoto T, Wakayama T, Mizokami A,
  Namiki M, Kawai K, Tamai I. Enhanced expression of organic anion transporting
  polypeptides (OATPs) in androgen receptor-positive prostate cancer cells:
  possible role of OATP1A2 in adaptive cell growth under androgen-depleted
  conditions. Biochem Pharmacol. 2012 Oct 15;84(8):1070-7. doi:
  10.1016/j.bcp.2012.07.026.

2010

• Maeda T, Irokawa M, Arakawa H, Kuraoka E, Nozawa T, Tateoka R, Itoh Y,
  Nakanishi T, Tamai I. Uptake transporter organic anion transporting polypeptide
  1B3 contributes to the growth of estrogen-dependent breast cancer. J Steroid
  Biochem Mol Biol. 2010 Oct;122(4):180-5. doi: 10.1016/j.jsbmb.2010.06.014.
• Fan X, Ross DD, Arakawa H, Ganapathy V, Tamai I, Nakanishi T. Impact of
  system L amino acid transporter 1 (LAT1) on proliferation of human ovarian
  cancer cells: a possible target for combination therapy with anti-proliferative
  aminopeptidase inhibitors. Biochem Pharmacol. 2010 Sep 15;80(6):811-8. doi:
  10.1016/j.bcp.2010.05.021.

2008

• Tani T, Gram LK, Arakawa H, Kikuchi A, Chiba M, Ishii Y, Steffansen B, Tamai
  I. Involvement of organic anion transporting polypeptide 1a5 (Oatp1a5) in the
  intestinal absorption of endothelin receptor antagonist in rats. Pharm Res. 2008
  May;25(5):1085-91. doi: 10.1007/s11095-007-9472-4.

総説

• Arakawa H, Matsushita K, Ishiguro N. Advanced in vitro evaluation of drug-induced kidney injury using microphysiological systems in drug discovery and development. Drug Metab Pharmacokinet. 2025 Apr;61:101056. doi:10.1016/j.dmpk.2025.101056.
• Wen S, Arakawa H, Tamai I. Uric acid in health and disease: From physiological functions to pathogenic mechanisms. Pharmacol Ther. 2024 Apr;256:108615. doi: 10.1016/j.pharmthera.2024.108615.
• Arakawa H, Kato Y. Emerging Roles of Uremic Toxins and Inflammatory Cytokines in the Alteration of Hepatic Drug Disposition in Patients with Kidney Dysfunction. Drug Metab Dispos. 2023 Sep;51(9):1127-1135. doi: 10.1124/dmd.122.000967.
• Mizoi K, Arakawa H, Yano K, Koyama S, Kojima H, Ogihara T. Utility of Three-
  Dimensional Cultures of Primary Human Hepatocytes (Spheroids) as Pharmacokinetic Models. Biomedicines. 2020 Sep 23;8(10):374. doi: 10.3390/biomedicines8100374.

日本語総説

• 荒川大. 腸肝臓器間相互作用による薬物動態変動の観測と分子メカニズムの解明.　薬学雑誌. 2023;143(2):101-104. doi: 10.1248/yakushi.22-00172.
• 荒川大. 尿酸の炎症反応を介した慢性腎臓病進展メカニズムと腎臓病態評価モデルの構築. 月刊細胞, 2023, 55:239-242.
• 加藤将夫、河西巧、荒川大. Organs-on-a-chip を利用した薬物動態における臓器間相互作用の理解．臨床薬理2020, 151:174-176.
• 荒川大、加藤将夫．腎・肝障害患者における薬物動態変動．医学のあゆみ 2017, 264:584-589.

学会賞

• 荒川大. 奨励賞, 生体環境を模倣する新規細胞培養技術の薬物動態・毒性研究への応用に関する研究, 日本薬剤学会. 2024年5月.
• 荒川大. 日本薬物動態学会奨励賞, 薬工連携による新規薬物動態評価手法の開発, 日本薬物動態学会. 2022年11月.
• 荒川大. 学術奨励賞, 腸肝臓器間相互作用による薬物動態変動の観測と分子メカニズムの解明, 日本薬学会北陸支部. 2021年11月.

優秀発表賞

• Hiroshi Arakawa. JSSX Best Poster Award, Utility of high content analysis of drug-induced kidney injury using 3D-cultured kidney epithelial cells, 2023 International Joint Meeting of ICCP450/JSSX. Sep, 2023.
• 荒川大. 大会長特別賞, 三次元培養ヒト初代近位尿細管上皮細胞を用いた薬物腎毒性の評価手法の構築, 日本動物実験代替法学会 第35回大会. 2022年11月.
• Hiroshi Arakawa et al., 4th APISSX Best Presentation Award, 1st Place, Upregulation of organic anion transporting polypeptide (OATP) 1A2 by depletion of androgens; a possible molecular mechanism of castration resistance in prostate cancer, 4th Asia Pacific Regional ISSX Meeting. Apr 2011.